Schizophrenia clinical trials - Search
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  1. Clinical Trials Arena
    https://www.clinicaltrialsarena.com/features/features-schizophrenia-trials-to-watch

    Schizophrenia: Four major clinical trials to watch in 2023

    • Learn about the novel mechanisms and endpoints of four late-stage trials in schizophrenia with readouts expected in 2023. The trials target total symptoms, negative symptoms, and treatment resistance of … See more

    Reviva, Newron, and Sunovion Target Total Symptoms

    In mid-2023, Reviva expects topline results for the 402-patient Phase III RECOVER trial of … See more

    Clinical Trials Arena
    Acadia Targets Negative Symptoms

    Acadia expects results in late 2023 or early 2024 for the 426-patient ADVANCE-2 trial of pimavanserin for the negative symptoms of schizophrenia (NCT04531982). Pimavanse… See more

    Clinical Trials Arena
    Drug Development in Schizophrenia

    Schizophrenia affects approximately 24 million people worldwide, and nearly one third of all cases go undiagnosed. Regulators have pushed strategies to improve cli… See more

    Clinical Trials Arena
    Systematic literature review of schizophrenia clinical practice ...
    Tani, H. et al. Factors associated with successful antipsychotic dose reduction in schizophrenia: a systematic review of prospective clinical trials and meta-analysis of randomized controlled...
    Nature · https://www.nature.com/articles/s4153…
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    Table of Contents
    Reviva, Newron, and Sunovion Target Total Symptoms
    Acadia Targets Negative Symptoms
    Drug Development in Schizophrenia
     

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  2. Several clinical trials are currently underway to test drugs for the treatment of schizophrenia1. These include:The standard clinical trial to assess the efficacy of a drug to treat schizophrenia lasts for six weeks after the onset of treatment, and patients are interviewed weekly by a trained rater to assess symptom severity with a test called the Positive and Negative Syndrome Scale (PANSS)2.
    Learn more:
    Phase III trials of Reviva Pharmaceuticals’s brilaroxazine, Newron Pharmaceuticals ’s evenamide, and Sunovion Pharmaceuticals ’s ulotaront are each targeting total symptoms of schizophrenia. Meanwhile, Acadia Pharmaceuticals ’s pimavanserin focuses on the negative symptoms of schizophrenia, which include apathy, withdrawal, and blunted effect.

    Schizophrenia: Four major clinical trials t…

    www.clinicaltrialsarena.com/features/features-schiz…
    Currently, the standard clinical trial to assess the efficacy of a drug to treat schizophrenia lasts for six weeks after the onset of treatment, and patients are interviewed weekly by a trained rater to assess symptom severity with a test called the Positive and Negative Syndrome Scale (PANSS).

    Improving Clinical Trials of Drugs to Tre…

    www.fda.gov/drugs/regulatory-science-action/impro…
     
  3. People also ask
    Should you participate in a clinical trial for schizophrenia?
    If you or someone you care about has schizophrenia, you might consider participating in a clinical trial to try to come up with a new treatment. Most people with the disease get a combination of medicine and therapy to manage their symptoms. But you may have to try different antipsychotic drugs to find one that helps you.

    Schizophrenia Clinical Trials - WebMD

    webmd.com
    What does available research indicate about the heritability of schizophrenia?

    Dr. Yalin Wang

    Doctor of Medicine (MBBS) · 6 years of exp

    Over the years, researchers have found that the chance of one twin suffering from schizophrenia if the other did was anywhere from 44 to 87 percent. The most common figure cited was 81 percent. And a 2012 analysis of records for all people in Denmark found that the chance of a schizophrenia patient's child suffering from schizophrenia was about 67 percent.
    Q&A: Schizophrenia
    bing.com
    How long does a clinical trial last for schizophrenia?
    The standard clinical trial for assessing the efficacy of a drug to treat schizophrenia lasts for six weeks after the onset of treatment. Patients are interviewed weekly by a trained rater using the Positive and Negative Syndrome Scale (PANSS) to assess symptom severity.

    Improving Clinical Trials of Drugs to Treat Schizophrenia

    fda.gov
    How has Pharma impacted clinical trials in schizophrenia?
    Regulators have pushed strategies to improve clinical trial design and cut costs in schizophrenia, and pharma has followed suit with more drug development investment. Despite this renewed push for treatments, there has only been a slight increase in trial initiations over the past decade, according to GlobalData’s Clinical Trials Database.

    Schizophrenia: Four major clinical trials to watch in 2023

    clinicaltrialsarena.com
    Could four late-stage clinical trial readouts in schizophrenia be a new glimmer of Hope?
    Despite significant advances in understanding the neurobiology of schizophrenia, treatment options have largely remained limited. But in 2023, four late-stage clinical trial readouts in schizophrenia could offer a new glimmer of hope.

    Schizophrenia: Four major clinical trials to watch in 2023

    clinicaltrialsarena.com
    Why do novel treatments for schizophrenia fail in clinical trials?
    Neuropsychopharmacology 49 , 321–322 ( 2024) Cite this article Why do novel treatments for schizophrenia ultimately fail in clinical trials? The heterogeneous underlying biological mechanisms of schizophrenia are likely responsible for these disappointments.

    A path to novel, effective treatments for schizophrenia - Nature

    nature.com
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  4. Nature
    https://www.nature.com/articles/d41586-024-03123-9

    Revolutionary drug for schizophrenia wins US approval - Nature

     
  5. JAMA Network
    https://jamanetwork.com/journals/jama…

    Efficacy and Safety of Xanomeline-Trospium Chloride …

    This randomized clinical trial evaluates the efficacy and safety of xanomeline-trospium chloride vs placebo in adults with schizophrenia.

  6. Nature
    https://www.nature.com/articles/s41398-022-01904-2

    Beyond antipsychotics: a twenty-first century update for preclinical ...

  7. The New England Journal of Medicine
    https://www.nejm.org/doi/full/10.1056/NEJ…

    Effectiveness of Antipsychotic Drugs in Patients with …

    Sep 22, 2005 · A total of 1493 patients with schizophrenia were recruited at 57 U.S. sites and randomly assigned to receive olanzapine (7.5 to 30 mg per day), perphenazine (8 to 32 mg per day), quetiapine (200...

  9. NIMH
    https://www.nimh.nih.gov/health/trials/schizophrenia

    Schizophrenia - National Institute of Mental Health (NIMH)

  10. Nature
    https://www.nature.com/articles/s41537-0…

    Systematic literature review of schizophrenia clinical …

    Feb 24, 2022 · Tani, H. et al. Factors associated with successful antipsychotic dose reduction in schizophrenia: a systematic review of prospective clinical trials and meta-analysis of randomized controlled...

  11. The Lancet
    https://www.thelancet.com/journals/lancet/article/...

    Efficacy and safety of the muscarinic receptor agonist KarXT ...

  12. Boehringer Ingelheim
    https://www.boehringer-ingelheim.com/us/media/...

    Schizophrenia: Trial Results Show Advance in Cognition | BI US

  13. Food and Drug Administration (.gov)
    https://www.fda.gov/drugs/regulatory-science...

    Improving Clinical Trials of Drugs to Treat Schizophrenia

  14. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC3792827

    Current approaches to treatments for schizophrenia spectrum …

  15. The Lancet
    https://www.thelancet.com/journals/lanpsy/article/...

    Pimavanserin for negative symptoms of schizophrenia: results …

  16. JAMA Network
    https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2758022

    Efficacy and Safety of Lumateperone for Treatment of Schizophrenia

  17. The Lancet
    https://www.thelancet.com/journals/lanpsy/article/...

    Efficacy and effectiveness of antipsychotics in schizophrenia: …

  18. Policy Lab
    https://policylab.us/clinical-trials/l/conditions/schizophrenia

    Schizophrenia Clinical Trials - Policy Lab

  19. Nature
    https://www.nature.com/articles/s41386-023-01705-1

    A path to novel, effective treatments for schizophrenia - Nature

  20. researcherprofiles.org
    https://ucla.clinicaltrials.researcherprofiles.org/schizophrenia

    UCLA Schizophrenia Clinical Trials for 2024 — Los Angeles

  21. Clinical Trials at University of California Health
    https://clinicaltrials.ucbraid.org/schizophrenia

    Schizophrenia clinical trials at University of California Health - UC …

  22. Clinical Trials at UCSF
    https://clinicaltrials.ucsf.edu/schizophrenia

    UCSF Schizophrenia Clinical Trials — San Francisco Bay Area

  23. Mayo Clinic Research
    https://www.mayo.edu/research/clinical-trials/...

    Schizophrenia Clinical Trials - Mayo Clinic Research

  24. Clinical Trials at UCSD
    https://clinicaltrials.ucsd.edu/schizophrenia

    UCSD Schizophrenia Clinical Trials for 2024 — San Diego

  25. WebMD
    https://www.webmd.com/schizophrenia/clinical...

    Clinical Trials for Schizophrenia - WebMD

  26. APA PsycNet
    https://psycnet.apa.org/record/2012-18337-011

    The Norwegian standardization of the MATRICS (Measurement …